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10.1016/s0140-6736(08)60132-4 19 ButtgereitF.SmolenJ

The human CoVs S protein ( Figure 1C ) facilitates host cell virus entry and subsequent membrane fusion allowing viral infection ( Figure 1C )

Iron chelators (like deferoxamine), ROS scavengers (like N-acetylcysteine) and the canonical ferroptosis inhibitor ferrostatin-1 all attenuate this cascade, underscoring the central role of microglia-driven iron dysregulation in SCI pathology ( Ferroptotic microglia themselves amplify inflammation