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These modifications preserve IGF-1 receptor (IGF-1R) agonist activity while reducing IGFBP sequestration, enabling sustained receptor engagement in preclinical research models

View on PubMed [PubMed] Fasting enhances growth hormone secretion and amplifies the complex rhythms of GH secretion in man (J Clin Invest, 1988) Demonstrated that fasting significantly amplifies pulsatile GH release in healthy men, both increasing pulse frequency and amplitude