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The darkening or dark patches occur due to excess production of the pigment melanin in some portions of the skin

This paper shows that the 'club drug' GHB downregulates RGS2 in VTA dopaminergic neurons, which reduces the rewarding properties of GHB through altered GABA B GIRK signalling

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3rd April Another fab treatment at debs stanway salon today skin booster Always excellent results be back in June for Botox so great to of got such a great service just up the road so easy to get to and park love going which is a big change as before I was always anxious extra good today debs mum there as well lovely lady see you again soon big thanks xx Back to see debs for more treatments can't keep away fab results and fab prices and love the salon in stanway such a lovely relaxing atmosphere be back next month so glad I found a place good as this only 20 mins away .thanks debs see you soon x Another trip to Deb's today for filler excellent job as always so professional love going there simply the best thanks debs 23/11/24 Another trip to see debs today love going there so professional approachable salon is lovely can park outside just whole experience faultless so glad found debs Debbie is absolutely fantastic it's a pleasure going there she is totally professional caring and amazing results what can I say except faultless can't wait to go and see Debbie again really soon Janet Bassett 2 years ago Saw Debbie first time today for skin boosters was nervous but soon felt at ease Debbie was lovely very knowledgeable and easy to talk to very happy Back to Debbie's today for Botox first time seen Debbie for Botox amazing no bruising and she is so professional and confident truly excellent thanks debs so glad I found you see you after Christmas x Jan 24 Thanks so much for today Deb your new salon is beautiful lovely bright and airy with some great decor cant wait to come back next month so great to of found someone as professional and competent as you at last