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Whilst previous work by Nagashima et al

From ~50,000 clones, 12 mutant strains that exhibited improved tyrosine hydroxylation capability compared with that of the strain expressing the wild-type enzyme were selected (Supplementary Fig

All major homeostatic functions of astrocytesincluding metabolic support, neurotransmitter and precursor homeostasis and metabolism, cholesterol synthesis, water transport, support of the glymphatic system, neurogenesis, neuroprotection and defensedecline with aging 133,182