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2.3 Neuroinflammation Some studies have shown that berberine activates macrophages and increases their phagocytic function, increases the production of interleukin (IL)-1, and enhances non-specific immunity, can be used as a neuroprotective agent to prevent Alzheimers disease (Kumazawa et al., 1984

J Appl Biomed 14:235245

Deglycyrrhizinated licorice (DGL)/licorice root: Licorice root, particularly in the DGL (processed form of licorice root), forms a protective coating on the stomach lining and may stimulate mucus production to alleviate irritation

Carotenoids may upregulate the activity of antioxidant enzymes, mainly via the activation of the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent pathway (Kaulmann and Bohn 2014)