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Mitochondrial DNA programs lactylation of cGAS to induce IFN responses in patients with systemic lupus erythematosus

Arom de fructe de pdure

This study contributes to our understanding of dAGEs as a risk factor for FA and highlights the potential of dAGEs restriction as a promising preventative strategy for susceptible populations

Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism