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Description

Effects appear more pronounced in earlier disease stages

doi: 10.1007/s40618-020-01477-1 6 RalliMAngelettiDFioreMD'AguannoVLambiaseAArticoMet al

En condiciones de sobreexpresin de NNMT, esta reaccin consume nicotinamida (un precursor del NAD+) y agota reservas de SAM, alterando el equilibrio metablico celular