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Accumulation of intermediates such as succinate and fumarate can act as metabolic signals that stabilize hypoxia-inducible factor 1 (HIF-1) and amplify inflammatory cytokine production, thus coupling mitochondrial dysfunction to inflammation 112,113

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Other types of GPXs have been shown to be expressed in the cochlea, for instance, GPX2 protein is greatly increased in chicken utricle HC expression during HC differentiation (Zhu et al., 2019) and cisplatin injury leads to the decreased GPX2 expression in HEI-OC1 cells (Youn et al., 2017

Subsequently, the cells were incubated with DAPI (1 g/ml