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One of its key neuroactive metabolites, allopregnanolone (ALLO), acts as a potent positive allosteric modulator of the -aminobutyric acid (GABA)_A receptor, enhancing inhibitory neurotransmission and exerting anxiolytic and antidepressant effects (22,62-64)

TLR4) and other innate immune sensors in peripheral tissues and the brain [35, 36]

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