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Although efforts to formulate efficient glutaminase inhibitors are not a completely new concept, they are yet to be approved for use in the clinical setting

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Intracellular GSH levels A2780 and A2780DDP cells were incubated for up to 24 h with 50 M of buthionine sulphoximine (BSO), which inhibits the GSH synthesis, and the intracellular GSH was measured (Figure 3)