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The problem is relatively common its thought to affect between 1% and 3% of the population

Ritchie Shoemaker on chronic inflammatory response syndrome (CIRS)

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency or establish a causal relationship to drug exposure: Blood and lymphatic system disorders:hemolytic anemia, leukocytosis Cardiac disorders:cardiospasm, congestive heart failure, conduction block, orthostatic hypotension and syncope, palpitations, bradycardia, atrial fibrillation, myocardial infarction, cardiac arrest, arrhythmia, ventricular ectopic activity, including ventricular tachycardia and QT prolongation

Therefore, they suggested that 3-BrPA inhibits PASMC proliferation and migration by suppressing glycolysis, effectively reversing vascular remodeling in rats with hypoxia-induced PAH [211]