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Secreted IGF-1 and VEGF inhibit GC apoptosis through the upregulation of Bcl-2 and proto-oncogene (c-myc), alongside the suppression of Bax and cyclin-dependent kinase inhibitor 1 A (p21) (Hu et al

Similarly, cultured macrophages of advanced atherosclerotic lesions are found to progressively accumulate TC, which stimulates PL biosynthesis as a response to protect the macrophages from TC-cytotoxicity

For example,a cohort study of depressive patients and healthy controls found that MTHFR polymorphism were more common in the individuals with depression history compared to controls 67 , while a study over a 60-month follow-up with depressed subjects indicated that the CC genotype of MTHFR C677T were more likely to have more severe symptoms compared to TT genotype carriers 68

Resources mentioned: Patrick Holford podcast episode about Alzheimers, homocysteine, B vitamins and omegas L-glutamine supplements Methylated B-vitamins Omega-3 supplements More from Liz: Preorder Lizs new book How to Age A Better Second Half More from Mo: Get in touch with a question for Liz: Email: [email protected] WhatsApp: 07518 471 846 Some links may be affiliate links, which help support the show at no extra cost to you