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Maintaining ROS within balance is supported by antioxidant systems, with endogeneous enzymatic antioxidants, such as superoxide dismutase (SOD) 76 , catalase (CAT) 77,78 , glutathione peroxidase (GPx) 79 and thioredoxin (Trx) 80 , as well as nonenzymatic antioxidants including vitamins such as vitamin C 81 , vitamin E 82 which collectively counter ROS overproduction within cells directly or indirectly 83