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Andrew Blumenfeld, a primary researcher in the PREEMPT clinical trial, says that Botox is injected shallowly into the muscle at 31 dedicated injection sites, all of which are around pain fibers since these sites are at sensory nerve-ending sites, they wont have the effect as if injected into cosmetic sites. The PREEMPT clinical trial produced the injection site locations and eventually led to the FDA approval of Botox as a migraine preventive treatment