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Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species

3.2.4 Alzheimers disease (AD) AD is a progressive neurodegenerative disorder of the central nervous system in the elderly, marked by cognitive impairment and characterized by cerebral amyloid plaques (mainly amyloid , A) and neurofibrillary tangles (NFT) (Naseri et al., 2019)