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Stress is a critical player in CYP3A, CYP2C, and CYP2D regulation: role of adrenergic receptor signaling pathways

Similarly, nine of the seventeen residues (Q637 3.29 , H641 3.33 , H721 ex2 , S726 5.39 , F730 5.43 , W775 6.48 , F778 6.51 , L782 6.55 , and C801 7.39 ) mediate activation by cyclamate, while six (Q637 3.29 , H641 3.33 , W775 6.48 , F778 6.51 , L782 6.55 , and C801 7.39 ) influence receptor inhibition by lactisole as well as receptor activation by cyclamate [superscript refers to the nomenclature suggested for class C GPCRs by Pin et al