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Tianma modulates (ER-resident) molecular chaperone proteins in differentiated neuronal N2a cells Skp1a : Decreased expressions of the ubiquitin-proteasome/E3 ligase component Skp1a and the chaperone Hsc-70 can lead to a wide impairment in the function of an entire repertoire of proteins in neurons [60] suggesting a new structural role of Skp1a in dopaminergic neuronal functions besides its E3 ligase activity [61]

PET tracers targeting transferrin receptors underperform in diffuse axonal injury, as injury boundaries are unclear and non-specific uptake occurs in perihematomal edema, resulting in signal levels below clinical detection thresholds