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Importantly, bivariate analyses revealed that these changes were almost exclusively present in individuals who reported to have quit smoking, which is in line with evidence showing that smoking cessation is associated with improvements in several psychophysiological health outcomes [3, 4]

The administration of nicotine into the LC, the A2 (norepinephrine-containing neurons) and C2 (epinephrine-containing neurons) regions of the nucleus of the tractus solitarius, and the A1 region of the ventrolateral medulla stimulates the release of ACTH (Matta et al., 1993b)