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The excessive buildup of ECM components, such as collagen, fibronectin, laminin, glycoproteins, proteoglycans, and various polysaccharides, in the tubulointerstitial space during fibrosis progression disrupt kidney structure, reduce blood supply, and impair renal function, which ultimately leads to irreversible kidney failure [7]

StbloMWaltonFHarmonASheridanPBeckM

Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA

The N-terminus mainly maintains the helical structure of -syn, and familial PD-associated mutations in the SNCA gene frequently occur in this region