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Description

It posits that the gut microbiota and its metabolites impact ferroptosis in IBD by regulating intestinal barrier function, modulating inflammatory factors, and maintaining immune homeostasis

Ledo A, Arduini A, Asensi MA, Sastre J, Escrig R, Brugada M, et al

Nat Genet (2011) 43(5):4426

S-adenosylmethionine (SAM), the methyl group donor substrate for DNMTs and HMTs, is formed in the one-carbon metabolism pathway, transformed to S-adenosylhomocysteine (SAH) during methylation, and then to homocysteine (HCys)