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Recall that NAD + is used to oxidize glucose to release energy

In these studies, impairment in mitochondrial function such as reductions in the activity of electron transport chain (ETC) enzymes, specifically complex I activity, and reduction of N-acetyl aspartate levels were found in the hippocampal region of the brain (Kunz et al., 2000

Salituro G

The results of the MTT assay showed that overexpression of ATF4 significantly promoted the proliferation of HuOCSCs in vitro and reduced the cell proliferation inhibition rate (Figure 6A)