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Copper: role of the endogenous and exogenous metal on the development and control of inflammatory processes

In particular, increased mitochondrial oxidative stress in fibroblast-derived induced pluripotent stem cells, differentiated into human nigral DA neurons, triggers a DA-dependent toxic cascade, leading to oxidized DA accumulation and reduction in glucocerebrosidase enzymatic activity, lysosomal dysfunctions, and -syn accumulation [49]