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These in vitro findings support the notion that ALC decreases cholesterol synthesis by downregulating SREBP2, thereby contributing to its lipid-lowering effects observed in vivo

We found that a considerable number of proteins and metabolites were both involved in mineral absorption, proximal tubule bicarbonate reclamation, inflammatory mediator regulation, lysosome, neuroactive ligand-receptor interaction, cAMP signaling pathway, biosynthesis of amino acids, purine metabolism, fructose and mannose metabolism, glycolysis/gluconeogenesis Fig

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