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Lancet (2018) 391:933

In addition, three samples were randomly selected from each group for the measurement of keratin, amino acids, especially the sulfur-containing amino acids, and content of S, O, and C by semi-quantitative detection analysis using an X-ray energy spectrometer (Genesis 2000, EDAX Inc.)

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Among these, only the phase III trial of entinostat combined with exemestane in treating hormone receptor-positive advanced breast cancer has shown satisfactory efficacy and manageable toxicities