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The increased production of butyrate, but also isobutyrate and isovalerate in vitro suggests that these 3 antioxidant molecules contributed to the maintenance and active resilience of host-bacterial mutualism against mucosal oxygen and uncontrolled oxidative stress in vivo

The fundamental features of ferroptosis, such as iron deposition, lipid peroxidation, glutathione (GSH) depletion, and glutathione peroxidase 4 (GPX4) inactivation, have been gradually emphasized in the pathogenesis of RA (9)

After controlling for several variables, including sex, age, history of polyps, medical conditions, medications, BMI, and another CRC-related nutritional status, the association between riboflavin and CRC risk remained and showed a dose-response link (104)

Among them, glutathione exists in two interconvertible forms: reduced glutathione (GSH) and its oxidized disulfide (GSSG), formed by the linkage of two GSH molecules via a disulfide bond