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Beyond the Smad pathways, TGF- also influences tissue fibrosis through non-Smad mechanisms such as the Ras-MAPK, PI3K-Akt, and Par6-Smurf1 pathways, while concurrently inhibiting the TGF--Smad pathway by encouraging I-Smad binding to active TRI, thus hindering R-Smad phosphorylation (6769)

Both models were applied initially to all participants with data on ANA regardless of data on smoking exposure (Total) and then within subgroups with data on both ANA and smoking exposure (None, Passive, and Active)

In people who smoke, the arteries that carry blood to the heart become narrowed over time

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