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doi: 10.1038/cdd.2010.150 64 ManganMSBirdCHKaisermanDMatthewsAYHitchenCSteerDLet al

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It can be prevented by GPX4-mediated detoxification of lipid peroxides [6,7,8,9] or by limiting cellular iron availability [10,11,12,13,14] (Fig

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As evident above, this catabolic pathway is active in many tissues, such as the kidneys, liver, bile ducts, brain and bone marrow

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