OSu-PEG4-VC-PAB-DMEA-Duocarmycin SA Size:1mg resulting in decreased CDK12 substrate

resulting in decreased CDK12 substrate phosphorylation

504 Purity (HPLC) >= 95% Solubility DMSO

Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target

where the Val-Cit-PAB motif enables enzyme-cleavable release of MMAE inside target cells

OSu-PEG4-VC-PAB-DMEA-Duocarmycin SA Size:1mg resulting in decreased CDK12 substrateOSu PEG4 vc PAB DMEA Duocarmycin SA is a cleavable ADC druglinker conjugate that couples the potent antitumor antibiotic Duocarmycin SA to an OSu PEG4 vc PAB DMEA linker. The DNA? modifying agents such as duocarmycin are increasingly used in the development of antibody? drug conjugates (ADCs), where they serve as highly potent cytotoxic payloads. Designed for ADC research, this construct supports efficient antibody conjugation, PEG4? enhanced