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Ophthalmology 125 , 815821 (2018)

Similarly, another animal model of colitis treated with other xanthine derivatives exhibited protective effects: Theophylline treatment reduced myeloperoxidase activity and TNF-, IL-1, and IL-6 in the colons in an acetic acid-induced colitis rat model [75]

The current treatment approaches include surgical resection often combined with radiochemotherapy, yet the median survival time of the most aggressive subtype, glioblastoma, is no longer than 15 months 1