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Furthermore, copper/iron ions have been found to affect the aggregation or toxicity of other disease-associated amyloid proteins (including -amyloid, tau, and prion proteins), suggesting new avenues for investigating other protein misfolding disorders (175)

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Many factors influence this progressive neurodegeneration including age, genetics, and high intraocular pressure (IOP) as well-established risk factors ( 2 Metabolic dysfunction in glaucoma 2.1 Metabolic changes to retinal ganglion cells in glaucoma Retinal ganglion cells are especially vulnerable to metabolic disturbances

Rufo, N., Garg, A