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Importantly, treatment of DIO mice with our NNMT inhibitors did not impact food intake, but produced marked reductions in body weight, WAT mass, adipocyte size, and cholesterol levels with negligible toxicity or observable adverse effects

T cells expressing this HBV-specific TCR secrete pro-inflammatory and antiviral cytokines, and selectively eliminate HBV-positive hepatoma cells and HBV-infected target cells, thereby clearing viral infection [18]

Acknowledgements The authors are grateful for the support received from the Austrian Science Fund (FWF, P 29379-B28), the Tyrolean Science Fund (TWF, 0404/1812), the Austrian Society of Gastroenterology and Hepatology (GGH) and the European Crohns and Colitis Organisation (ECCO) (to T.E.A.)

The resulting tissue damage further promotes the proliferation and enhanced virulence of pathogens such as P