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Furthermore, Shamansoori et al

97 IDA's complex pathogenesis might be driven by a lowered erythropoietin response, decreased RBC survival along with reduced iron absorption and macrophageal iron retention, limiting iron delivery to erythroid precursor cells

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Additionally, other studies have indicated that madecassoside can significantly inhibit the migration ability of KFs by suppressing the activity of the p38 mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways, reducing the phosphorylation level of cofilin, and decreasing the formation of F-actin filaments