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A further, less well-described auxotrophy is for glutamine, through loss or downregulation of glutamine synthetase (GS), which has been described in multiple myeloma, ovarian cancer and oligodendroglioma cells

Unresolved inflammation results in formation of vulnerable plaques, which have large necrotic cores and a thinning fibrous cap (Figure 5)

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Consequently, changes in the ROS levels inside the cancer cells in a 1% O 2 atmosphere were examined by utilizing the ROS specific probe 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA) which is chemically converted into a green fluorescent dye in the action of ROS