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Finally, while MR methods are indeed reliable for causal inference, it is crucial to acknowledge the necessity of further validation through a randomized controlled trial in order to enhance the credibility and robustness of the findings presented in this MR study

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The temporal dynamics of histone lactylation modifications warrant particular attention, as exemplified in myocardial infarction, where H3K18 lactylation demonstrates distinct patterns during various phases of cardiac repair [20]