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Not because they're unsafe, but because the weight loss magnitude in controlled trials wasn't commercially viable compared to GLP-1 agonists or other obesity drugs

Advantages of using bacteriostatic water for the semaglutide reconstitution are longer stability of the reconstituted solution, state protection of the solution during storage and administration, and sterility preservation of the solution during multiple use

However, in patients other than neonates, ceftriaxone and calcium-containing solutions may be administered sequentially of one another if the infusion lines are thoroughly flushed between infusions with a compatible fluid (see WARNINGS)

Morava E, Wevers RA, Cantagrel V, Hoefsloot LH, Al-Gazali L, Schoots J, et al