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Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

We use LaccID proximity labeling and mass spectrometry to map the changing surface proteome of T cells that engage with tumor cells through antigen-specific T cell receptors

Consequently, glutathione concentration reached only 367 mg/L, notably lower than the 791 mg/L achieved under batch fermentation conditions

Alongside impairments in carbohydrate metabolism, evidence of reduced carnitine levels suggest a dysfunction in mitochondrial -oxidation, leading to accumulation of long-chain fatty acids and elevated markers of lipid elongation and desaturation (Filipek et al., 2004