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Some animal and early-phase studies noted elevated inflammatory cytokines (IL-6, TNF-) at higher doses, though clinical relevance in humans at therapeutic doses remains unclear

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These small bones join to each other at the IP joint (Interphalangeal Joint) and to the bone at the thumb side of the palm (1st metacarpal) at the MCP joint (Metacarpophalangeal Joint) forming 2 joints for the thumb (figure 1)