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By addressing these critical gaps, the translational potential of TCM-derived AMPK modulators in NAFLD management can be more rigorously evaluated

10.1038/nature09922 8

Furthermore, -hydroxybutyrate serves as the primary source of acetyl-CoA in T cells, facilitating H3K27ac at promoters of effector gene loci (e.g., Ifng , Gzmb and Tbx21 ), thereby augmenting cytokine production in CD8 + T cells (e.g., IFN-, TNF-) and modulating cellular immune functions