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Notably, RT-qPCR analysis showed a sharp increase in OCT4 mRNA expression, a marker of pluripotent stem cells and essential for TIC self-renewal [33], in the colonies formed in 3D gels relative to 2D culture conditions (Fig

Although the role of xCT in neurodegeneration and neuroprotection remains paradoxical, arsenic-induced upregulation suggests its indispensability for survival in stress condition

DOX alters myocardial ETC gene expression and translation in vivo , reducing the redox cycle of the ETC complex I, and generates large amounts of ROS (56)