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That is one more reason I like whole, less processed food

The nucleus is the control center of eukaryotic cells and previous studies reported the expression of various kinds of ABC transporters such as P-gp on the membrane of the nucleus and its role in resistance to various anti-cancer drugs like doxorubicin in various cancers such as glioblastoma multiform (LN-299) [234,235,236,237]

Synnot A, Chau M, Pitt V, OConnor D, Gruen RL, Wasiak J, Clavisi O, Pattuwage L, Phillips K

The supernatant was collected as the soluble fraction, while the pellet (insoluble fraction) was further processed to extract the detergent-soluble fraction