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Increased hepatic GST activity was also reported in some MASLD animal models as compared to control groups (Ali et al

Therefore, we call for studies that address iron accumulation in the brain in BD patients, using QSM and in postmortem tissues of BD patients

202,203 Essentially, the imported disulphide-containing proteins undergo cathepsin-catalysed degradation in the lysosome, leading to the formation of cystine, which is then effluxed by the cystinosin transporter into the cytosol, where it is reduced to cysteine in a process that requires NADPH, leading to the formation of oxidised glutathione