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Description

162 The mechanisms of intestinal absorption and hepatic uptake of exogenously administered SAM, and the mechanism of its hepatoprotection remain unknown

For example, a patient with a normal baseline may have drug interrupted at 5 x ULN, whereas a patient with a baseline ALT of 2 x ULN will reach interruption at 7 x ULN, resulting in the degree of permitted ALT elevation before interruption being proportional to the baseline ALT value