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Description

The LPS-TLR4-JNK/NF-B axis disrupts mitochondrial membrane potential and cristae architecture while downregulating Parkin expression, thereby blocking PINK1/Parkin-mediated mitochondrial autophagy

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CACT deficiency is a rare autosomal recessive disorder caused by SLC25A20 deficiency (Rubio-Gozalbo et al., 2004)

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