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These compounds exhibit selective binding to NEDD4 over other family members, effectively inhibiting NEDD4-mediated polyubiquitination while leaving monoubiquitinated substrates unaffected

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During this process, PLA particles were colonized by gut microbes, forming surface biofilms and increasing pullulanase activityan enzyme that degrades branched polysaccharidesthe authors suggested this may have broken down PLA into smaller carbon-rich molecules, potentially supporting Bifidobacterium growth, without triggering pathogenic overgrowth or inflammatory responses (Jimnez-Arroyo et al., 2023)

TCA cycle defects and cancer: When metabolism tunes redox state