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Differential effects of carvedilol and metoprolol on isoprenaline-induced changes in beta-adrenoceptor density and systolic function in rat cardiac myocytes

XL184 and XL880 are orally available, non-selective inhibitors, with high binding affinity to both Met and VEGFR and to a lesser extent to other receptor tyrosine kinases such as PDGFR, Ret, Kit, Flt-3 and Tie-2 (Liu et al., 2010)