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The liver-specific enzyme, alanine-glyoxylate aminotransferase (AGXT), plays a central role in catalysing glycine formation from glyoxylate 12,13,14 and recent transcriptomics studies from our group and others consistently reported suppression of AGXT in livers from patients and mice with MASH 12,15,16,17

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Since VDZ selectively binds to the integrin 4 7 , blocking its interaction with MAdCAM-1, we then looked at the ratio of 4 7 + cells in the biopsies relative to the blood for each subset, and found that VDZ significantly decreased 4 7 + cells in colon biopsies in the majority (21 of 23) cell subsets to varying extents (Fig