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In doing this, the potential of therapies that have a significant impact on a small subset is lost within the larger sample population

Since vitamin D is a potent stimulator of LL-37 production, this may partially explain the links seen between vitamin D deficiency and increased risk of infections, especially respiratory infections

Such targeting has the potential to make targeted drug delivery possible, allowing therapeutic factors that can damage the healthy part of the brain to be delivered only to the diseased region

The autophagic degradation of BMAL1 and CLOCK, termed Clockophagy, is a recently identified pathway for ferroptosis [93], which could intersect with BD pathogenesis