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Our findings show that the hypermethylation of ACB promoter genes, while strongly correlated with ACB expression and drug sensitivity, is not a primary cause of impaired adaptation to ROS stress since pre-treatment with demethylating drug did not unlock the NRF2 regulon (Fig

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Additionally, it pioneered the regulation of mitochondrial metabolites as an anti-inflammatory treatment for ocular conditions, presenting a safe, efficient, and innovative therapeutic strategy for DED and other inflammatory diseases

doi: 10.1016/j.jalz.2011.05.2351, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Sperling R., Salloway S., Brooks D