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Oxidative Medicine and Cellular Longevity 2012:324832

N., Ghosh, S

There had been different reports about polyamine enhancing the proliferation of cancers like breast, colon, lung, prostate, and skin cancers [125]

This mechanistic insight is strongly supported by in vivo evidence showing that anti-OPN antibodies, which mimic the effect of blocking thrombin-cleaved OPN, replicate a tumor suppression phenotype in knock-in mice engineered with a thrombin cleavage-resistant form of the protein [271]