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2A, 2 B and 2 C show (A) Urinary (B) Fecal elimination and (C) tissue retention respectively (expressed as percent of administered dose) of IV administered Co-60 in Fisher F344 rats: effect of repetitive treatment (once daily for 5 days) with ReadiSorb (oral) or non-formulated reduced glutathione (oral or IV)

Long-Term Use Concerns: Continuous or frequent use of period delay medication may not be advisable due to potential long-term side effects

Thus, therapeutics targeting PNPLA3, but not ANGPTL3, may be contraindicated should the outcome yield exacerbated ASCVD